12 villages of western Kefalonia were completely destroyed by the earthquake (Kato, Ano, Nisochori, Thynnios, Dellaportata, Kouralata, Metaxata, Kalligata, Schinia, Agia Thekla Poriorata and Varoskia), and two from Lixouri. 224 people lost their lives, 2,612 houses collapsed and 2,946 were damaged. Less damages were in Argostoli, where the coastal zone was mainly affected. There were landslides and landslides, and a slight tsunami was observed.

The earthquake was felt in central and southern Greece, southern Italy and the area of ​​present-day Albania. Minor damage was caused in Ithaca, Lefkada, Zakynthos, Corfu and Western Solid Greece.

The aftershocks continued for months in Kefalonia and by the end of April there was no day without earthquakes. Some of them were so powerful that they were felt in mainland Greece as well. The devastating earthquake triggered a migratory stream, and a major campaign in support of the earthquake relief effort was initiated by the Koumoundourou government and by Kefalonians from the diaspora.